Mitochondrial Dysfunction in PCOS: Insights into Reproductive Organ Pathophysiology

Polycystic ovary syndrome (PCOS) is a complex, but relatively common endocrine disorder associated with chronic anovulation, hyperandrogenism, and micro-polycystic ovaries. In addition to reduced fertility, people PCOS have higher risk of obesity, insulin resistance, metabolic disease, all comorbidities that are mitochondrial dysfunction. This review summarizes human animal data report dysfunction dysregulation in better understand how mitochondria impact reproductive organ pathophysiology. in-depth considers the elements regulating quantity quality, from biogenesis under transcriptional regulation both nuclear genome ultrastructural functional complexes regulate cellular metabolism reactive oxygen species production, as well dynamics subcellular interactions key quality control. When any these functions disrupted, energetic equilibrium within cell changes, processes can fail, death occur. If this process ongoing, it affects tissue function, causing disease. The objective consolidate classify broad number studies various organs, including (oocytes granulosa cells), uterus, placenta, circulation, A secondary uncover potential role transgenerational transmission disorders.